Southeast Asia is one of the important destinations for Chinese textile and garment enterprises to seek overseas investment. Since March 2021, the COVID-19 epidemic in Southeast Asia has spread rapidly, and the number of cases has surged. Chinese-funded textile and garment enterprises in Myanmar, Cambodia, Vietnam, and Bangladesh have also been hit by the COVID-19 epidemic. In this context, from March to June 2021, the responsibility office of the China Textile Federation carried out research work to understand the impact of the COVID-19 epidemic on the social responsibility of overseas Chinese textile and garment enterprises.